| 181357 | G5EE86 | TTX3_CAEEL | LIM/homeobox protein ttx-3 (Abnormal thermotaxis protein 3) | DISRUPTION PHENOTYPE | Animals are cryophilic and move toward lower temperatures irrespective of cultivation temperature in contrast to wild-type animals which move toward their cultivation temperature when placed on a temperature gradient. AIA and AIY interneurons display defective neurite morphology. NSM neurons display loss of or reduced expression of a number of terminal identity markers including cat-4, flp-4, bas-1, ptps-1 and mgl-1. Reduced expression of ceh-23, kal-1, C36B7.7, ser-2, unc-17 and sra-11 is observed in AIY interneurons. Preexposure to odorants fails to leave an olfactory imprint. Mean lifespan is reduced by 10% with decreased pharyngeal pumping and increased intestinal autofluorescence caused by lysosomal deposits of lipofuscin, indicative of cellular damage and aging. Formation of very few dauers in starvation conditions. No defects observed in brood size, egg number or chemotactic behavior toward volatile chemicals. {ECO:0000269|PubMed:11493519, ECO:0000269|PubMed:16051801, ECO:0000269|PubMed:21055415, ECO:0000269|PubMed:24353061, ECO:0000269|PubMed:9292724}. |