Mine Disruption Phenotype

Gene Info

  • Species:Worm (Caenorhabditis elegans)
  • GeneID:181471
  • Symbol:sad-1
  • Description:Serine/threonine kinase SAD-1
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Gene ID Entry Entry Name Protein Name Type Information
181471 Q19469 SAD1_CAEEL Serine/threonine kinase SAD-1 (EC 2.7.11.1) (Synapses of Amphids Defective) DISRUPTION PHENOTYPE Pre-synaptic vesicle and active zone proteins fail to be restricted to the axons of motor and sensory neurons. Synaptic vesicles fail to form tight clusters implying aberrant synaptic organization in addition to defects in neuronal polarity. Overexpression causes mislocalization of vesicle proteins to dendrites. {ECO:0000269|PubMed:11182085, ECO:0000269|PubMed:17151015}.