Gene ID | Entry | Entry Name | Protein Name | Type | Information | 181471 | Q19469 | SAD1_CAEEL | Serine/threonine kinase SAD-1 (EC 2.7.11.1) (Synapses of Amphids Defective) | DISRUPTION PHENOTYPE | Pre-synaptic vesicle and active zone proteins fail to be restricted to the axons of motor and sensory neurons. Synaptic vesicles fail to form tight clusters implying aberrant synaptic organization in addition to defects in neuronal polarity. Overexpression causes mislocalization of vesicle proteins to dendrites. {ECO:0000269|PubMed:11182085, ECO:0000269|PubMed:17151015}. |
---|