| 181472 | Q9XTR1 | CDK4_CAEEL | Cyclin-dependent kinase 4 homolog (CDK4/6) (EC 2.7.11.22) (Cell division protein kinase 4) | DISRUPTION PHENOTYPE | Arrested cell division in the G1 phase during larval development (PubMed:25562820). RNAi-mediated knockdown results in L4 stage arrest which is associated with uncoordinated movements and a protruding vulva (PubMed:10518501). Impaired cell division of P blast cells, somatic gonad precursors Z1 and Z4 and intestinal cells (PubMed:10518501). Severe defect in the proliferation of P blast cells, intestinal cells, vulva cell precursors and somatic gonad precursors (PubMed:10518501). Mesoblast M cell division is normal (PubMed:10518501). Double knockout with lin-35 rescues the cell cycle progression defect in the single cdk-4 mutants (PubMed:11684669, PubMed:25562820). {ECO:0000269|PubMed:10518501, ECO:0000269|PubMed:11684669, ECO:0000269|PubMed:25562820}. |