Mine Disruption Phenotype

Gene Info

  • Species:Worm (Caenorhabditis elegans)
  • GeneID:181727
  • Symbol:aak-2
  • Description:5'-AMP-activated protein kinase catalytic subunit alpha-2
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Gene ID Entry Entry Name Protein Name Type Information
181727 Q95ZQ4 AAPK2_CAEEL 5'-AMP-activated protein kinase catalytic subunit alpha-2 (AMPK subunit alpha-2) (EC 2.7.11.1) DISRUPTION PHENOTYPE Shortened life-span (PubMed:15574588, PubMed:18408008). Temperature-dependent hypersensitivity to stress, slow body bending, abnormal modulation of head oscillation (PubMed:15574588, PubMed:18408008). Reduced survival following oxidative stress induced by the superoxide paraquat (PubMed:24763318). Reduced survival as a result of hyperosmotic stress induced by NaCl (PubMed:26439621). Double knockout with aak-1 results in reduced glycogen accumulation (PubMed:26439621). {ECO:0000269|PubMed:15574588, ECO:0000269|PubMed:18408008, ECO:0000269|PubMed:26439621}.