| 182450 | Q9N5Z2 | OIG1_CAEEL | Immunoglobulin domain-containing protein oig-1 | DISRUPTION PHENOTYPE | Viable with locomotory defects which may be attributed to impaired GABAergic motor neuron function (PubMed:26387713, PubMed:26083757). Hypersensitive to the drug aldicarb which may be indicative of abnormal GABAergic signaling (PubMed:26083757). Premature postsynaptic remodeling/formation of DD GABAergic motor neurons in animals at larval stage L1 with remodeling/formation occurring 8-16 hours posthatching as opposed to 14-18 hours posthatching in wild-type animals (PubMed:26387713). Mislocalization of postsynaptic proteins with increased dorsal to ventral translocation of the acr-12 receptor in VD GABAergic motor neurons at larval stages L2 and L4; leading to no acr-12 puncta in the dorsal nerve and probably contributing to improper formation of synaptic inputs and ectopic postsynaptic remodeling/formation of VD motor neurons (PubMed:26387713, PubMed:26083757). Abnormal ectopic clustering of the postsynaptic receptor unc-49 along the dorsal nerve cord of DD GABAergic motor neurons (PubMed:26083757). Abnormal clustering of the presynaptic proteins snb-1 and rab-3 along the dorsal nerve cord of DD GABAergic motor neurons (PubMed:26083757). Additionally, aberrant localization of presynaptic proteins in VD GABAergic motor neurons with increased puncta for presynaptic proteins including snb-1, rab-3 and syd-2 in the dorsal nerve cord, but fewer puncta in the ventral nerve cord at larval stages proceeding the L1 larval stage, probably indicative of impaired and ectopic presynaptic remodeling/formation (PubMed:26387713, PubMed:26083757). {ECO:0000269|PubMed:26083757, ECO:0000269|PubMed:26387713}. |