| 183457 | Q18612 | HND1_CAEEL | Hand transcription factor 1 | DISRUPTION PHENOTYPE | Adults are viable and fertile, but with a moderate frequency of somatic gonad defects, which increases on an ehn-3 mutant background (PubMed:12756172). Low frequency of embryonic lethality, with embryos arresting paralyzed at the two-fold stage; increases in frequency significantly on an hlh-1 or unc-120 mutant background (PubMed:12756172, PubMed:15892873, PubMed:17142668). Many embryos that survive to hatch become uncoordinated, dumpy larvae with variable body shape defects, typically in the posterior (PubMed:15892873, PubMed:12756172). One quarter of the embryos from homozygous hnd-1;hlh-1 heterozygous parents exhibit reduced expression of myosin myo-3 (PubMed:17142668). On a unc-120 mutant background, progeny show reduced expression of myo-3 at mid-embryogenesis (PubMed:17142668). RNAi-mediated knockdown results in abnormal number and positioning of the somatic gonadal precursor cells (SGPs) and influences the maintenance of primordial germ cells (PGCs) in L1 larvae (PubMed:15892873). {ECO:0000269|PubMed:12756172, ECO:0000269|PubMed:15892873, ECO:0000269|PubMed:17142668}. |