| 190006 | G5ECW5 | CSP3_CAEEL | Non-catalytic caspase homolog csp-3 | DISRUPTION PHENOTYPE | Hatching is impaired in 5-6 percent of mutant embryos and about 2 percent of adults have uncoordinated movement (PubMed:18776901). In the anterior pharynx of L4 larvae, several cells including muscle and neuronal cells that normally survive during development are missing (PubMed:18776901). Slight increase in the number of cell corpses during embryonic development (PubMed:18776901). In a ced-5 n1812 or ced-6 n2095 mutant background, where cell corpse engulfment is defective, the number of cell corpses during embryonic development and in L1 larvae is further increased (PubMed:18776901). In a ced-3 n2427 or ced-3 n2427 and cps-3 n4872 mutant background, no extra pharyngeal cells caused by impaired apoptosis are produced (PubMed:23505386). In a csp-3 n4872, csp-1 n4967 and ced-3 n3692 mutant background, pharyngeal cells, that are normally fated to die, survive and 16 percent of animals have still 1 or more cell corpses that are morphologically apoptotic and are internalized by engulfing cells (PubMed:23505386). In addition, apoptosis of the male linker cell occurs normally (PubMed:23505386). {ECO:0000269|PubMed:18776901, ECO:0000269|PubMed:23505386}. |