| 190400 | G5EEN4 | GCK3_CAEEL | Germinal center kinase 3 (EC 2.7.11.1) (STE20-like serine/threonine kinase) | DISRUPTION PHENOTYPE | Hermaphrodites arrest after the first molt and die after at most 6 days. Most animals appear L2-like with morphologies of gonads and vulva that are out of step with the developmental stage. Mutants have a dilated intestinal lumen with extensive internal folding associated with the accumulation of undigested bacteria and a shortened excretory canal. Some animals have adult-type alae and are sterile with vulva and germ line formation defects (PubMed:20595048). In RNAi-mediated knockdown, impaired survival and slower volume recovery upon hypertonic stress (PubMed:17596296). {ECO:0000269|PubMed:17596296, ECO:0000269|PubMed:20595048}. |