| 191199 | O01775 | NEKL2_CAEEL | Serine/threonine-protein kinase nekl-2 (EC 2.7.11.1) (Never in mitosis A kinase-like 2) (NimA-kinase-like 2) | DISRUPTION PHENOTYPE | Failure to shed the cuticle at the end of the first molt resulting in an arrest at the L1 to L2 transition stage. RNAi-mediated knockdown results in a less severe phenotype characterized by a failure to shed the cuticle only in the middle part of the body at the end of the first molt. In hyp7 syncytium, RNAi-mediated knockdown results in the apical membrane accumulation of lrp-1 and mislocalization of several components of the endocytic machinery. {ECO:0000269|PubMed:25523392}. |