| 191743 | Q17446 | PMK1_CAEEL | Mitogen-activated protein kinase pmk-1 (EC 2.7.11.24) (Stress-activated protein kinase pmk-1) (p38 MAP kinase 1) | DISRUPTION PHENOTYPE | Knockout causes reduction in adult lifespan (PubMed:29748542). Upon infection by P.aeruginosa or E.faecalis, RNAi-mediated knockdown results in a decrease in survival rate and in a reduced up-regulation of gst-4 and gcs-1 expression (PubMed:12142542, PubMed:22216003). Causes a severe reduction in rnt-1 accumulation in the intestine during oxidative stress mediated by paraquat (PubMed:22308034). Upon exposure to C.cinerea galectin Cgl2, adults show reduced survival and larvae do not develop (PubMed:20062796). Larval development is partially restored in a bre-1, fut-8, gly-13, galt-1 or ger-1 mutant background (PubMed:20062796). {ECO:0000269|PubMed:12142542, ECO:0000269|PubMed:20062796, ECO:0000269|PubMed:22216003, ECO:0000269|PubMed:22308034, ECO:0000269|PubMed:29748542}. |