| 3565921 | Q9N3Z3 | CHK1_CAEEL | Serine/threonine-protein kinase chk-1 (EC 2.7.11.1) | DISRUPTION PHENOTYPE | RNAi-mediated knockdown leads to premature cell-cycle reentry of the Z2/Z3 primordial germ cells in L1 stage larvae (PubMed:26073019). RNAi-mediated knockdown and DNA damage induced by the ribonucleotide reductase inhibitor hydroxyurea in germ cells results in impaired DNA repair, but does allow for nuclear division (PubMed:27956467). In the proliferative zone of these germ cells, nuclei do not arrest following DNA damage, but prematurely divide and are smaller compared to wild-type (PubMed:27956467). {ECO:0000269|PubMed:26073019, ECO:0000269|PubMed:27956467}. |