Mine Disruption Phenotype

Gene Info

  • Species:Fly (Drosophila melanogaster)
  • GeneID:31293
  • Symbol:N
  • Description:Notch
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Gene ID Entry Entry Name Protein Name Type Information
31293 P07207 NOTCH_DROME Neurogenic locus Notch protein [Cleaved into: Processed neurogenic locus Notch protein] DISRUPTION PHENOTYPE RNAi-mediated knockdown in the larval brain neuroblasts abolishes the expression of pnt, induces the ectopic expression of erm, results in the ectopic expression of Ase in type II neuroblasts (NBs) and their premature loss (PubMed:18342578, PubMed:23056424, PubMed:27151950). Simultaneous RNAi-mediated knockdown of pnt partially restores normal neuroblast numbers and inhibits ectopic erm expression (PubMed:27151950). {ECO:0000269|PubMed:18342578, ECO:0000269|PubMed:23056424, ECO:0000269|PubMed:27151950}.