| 31519 | Q9W462 | UBP30_DROME | Ubiquitin carboxyl-terminal hydrolase 30 homolog (dUSP30) (EC 3.4.19.12) (Deubiquitinating enzyme 30 homolog) (Ubiquitin thioesterase 30 homolog) (Ubiquitin-specific-processing protease 30 homolog) (Ub-specific protease 30 homolog) | DISRUPTION PHENOTYPE | RNAi-mediated knockdown rescues the defective mitophagy caused by mutations in parkin and improves mitochondrial integrity in park- or PINK1-deficient flies. Moreover, knockdown in dopaminergic neurons protects flies against paraquat herbicide toxicity in vivo, ameliorating defects in dopamine levels, motor function and organismal survival. {ECO:0000269|PubMed:24896179}. |