Mine Disruption Phenotype

Gene Info

  • Species:Fly (Drosophila melanogaster)
  • GeneID:318680
  • Symbol:HEATR2
  • Description:HEAT repeat containing 2
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Gene ID Entry Entry Name Protein Name Type Information
318680 Q8INF7 DAAF5_DROME Dynein axonemal assembly factor 5 (HEAT repeat-containing protein 2 homolog) DISRUPTION PHENOTYPE Homozygous deletion-mutant flies are not viable. The larvae are smaller but do not display obvious morphological phenotype. RNAi-mediated knockdown in sensory neurons affects flies movement coordination and impairs hearing. Testis-specific RNAi-mediated knockdown does not alter spermatogenesis and in particular the formation of sperm axonemes but it impairs sperm motility. {ECO:0000269|PubMed:25232951}.