| 32948 | Q0KHQ5 | TAO_DROME | Serine/threonine-protein kinase Tao (EC 2.7.11.1) | DISRUPTION PHENOTYPE | Morphological defects in the follicular epithelium where cells in the anterior part of the epithelium stay cuboidal and fail to stretch (PubMed:23266957). RNAi-mediated knockdown in eye and wing imaginal disks results in tissue overgrowth (PubMed:22075147, PubMed:22075148). It also gives rise to transcriptional up-regulation of a number of targets of the Hippo/SWH pathway (PubMed:22075147). RNAi-mediated knockdown in wing imaginal disks results in strong elevation of yki activity (PubMed:22075148). RNAi-mediated knockdown in the adult posterior midgut results in an increased number of intestinal stem cells (PubMed:25160975). RNAi-mediated knockdown in the embryo results in disordered migration of primordial germ cells out of the gut epithelium, their dispersal within the embryo and embryonic death (PubMed:25589578). {ECO:0000269|PubMed:21248138, ECO:0000269|PubMed:22075147, ECO:0000269|PubMed:22075148, ECO:0000269|PubMed:23266957, ECO:0000269|PubMed:25160975, ECO:0000269|PubMed:25589578}. |