Mine Disruption Phenotype

Gene Info

  • Species:Fly (Drosophila melanogaster)
  • GeneID:33343
  • Symbol:chinmo
  • Description:Chronologically inappropriate morphogenesis
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Gene ID Entry Entry Name Protein Name Type Information
33343 Q9VQ30 CHNMO_DROME Zinc finger protein chinmo (Protein chronologically inappropriate morphogenesis) DISRUPTION PHENOTYPE Inappropriate morphogenesis of larval mushroom body neurons with early-born neurons adopting the fate of late-born neurons from the same lineage (PubMed:17055440). Malformed eyes and head capsules due to defects in eye progenitor cells (PubMed:20412771). RNAi-mediated knockdown in adult cyst stem cells and early cyst cells results in the appearance of cells resembling ovarian follicle cells throughout the testis (PubMed:25453558). RNAi-mediated knockdown in adult cyst stem cells results in loss of expression of the male-specific isoform of transcription factor dsx and leads to male sterility (PubMed:29389999). RNAi-mediated knockdown in imaginal wing disks results in decreased levels of nuclear actin (PubMed:26021350). RNAi-mediated knockdown in adult ovary somatic stem cells results in ovaries which are morphologically indistinguishable from the wild-type while ectopic expression in the adult ovary is sufficient to induce male fate in somatic cells (PubMed:26811385). {ECO:0000269|PubMed:17055440, ECO:0000269|PubMed:20412771, ECO:0000269|PubMed:25453558, ECO:0000269|PubMed:26021350, ECO:0000269|PubMed:26811385, ECO:0000269|PubMed:29389999}.