| 34952 | O61722 | PRL1_DROME | PRL-1 phosphatase (EC 3.1.3.48) (Phosphatase of regenerating liver-1) | DISRUPTION PHENOTYPE | Viable (PubMed:31404830, PubMed:31048465). Results in delayed hatching, locomotor defects and inability to fly (PubMed:31048465). Results in defects in axonal target areas in several central nervous system circuits (PubMed:31048465). Results in axonal and synapses defects in two distinct brain neuropils in the antennal lobes and mushroom bodies, respectively related to olfaction and olfaction-associated learning (PubMed:31048465). Reduces size of the central nervous system neuropil (a region of densely packed axons, dendrites, and synapses) (PubMed:31048465). When exposed to high concentration of carbon dioxide treatment results in a vertical held-up wing phenotype with calcium hyperactivation of neurons in the antennal lobe (PubMed:31404830, PubMed:31048465). Results in loss of synaptic arborizations from the contralateral mechanosensory neuron axon collateral with no defect in morphology (PubMed:31048465). RNAi-mediated knockdown in mechanosensory neurons eliminates terminal arbors and reduces numbers of synapses in the contralateral projecting axon collateral (PubMed:31048465). {ECO:0000269|PubMed:31048465, ECO:0000269|PubMed:31404830}. |