Mine Disruption Phenotype

Gene Info

  • Species:Fly (Drosophila melanogaster)
  • GeneID:35197
  • Symbol:brat
  • Description:brain tumor
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Gene ID Entry Entry Name Protein Name Type Information
35197 Q8MQJ9 BRAT_DROME Brain tumor protein DISRUPTION PHENOTYPE In larval brain, results in deregulated cell cycle and defective differentiation of immature intermediate neuroblast progenitors ultimately leading to overgrowth and proliferation (PubMed:16564014, PubMed:18342578). RNAi-mediated knockdown in the larval brain results in overproliferation of type II neuroblast cells on the dorsal side of the larval brains but had no effect in the type I neuroblast lineage in the ventral nerve cord (PubMed:22143802, PubMed:18342578). {ECO:0000269|PubMed:16564014, ECO:0000269|PubMed:18342578, ECO:0000269|PubMed:22143802}.