| 35800 | Q26263 | DPN_DROME | Protein deadpan | DISRUPTION PHENOTYPE | Lethal at different developmental stages (PubMed:1427077). In late third instar larval brains, results in a complete absence of type II neuroblasts (NBs) and a reduction of type I NBs; after larval hatching, loss of neuroblasts in the ventral nerve cord and specific loss of type I neuroblasts within 48 hours; in the pupae, results in a premature loss of mushroom body NBs (PubMed:23056424, PubMed:21262215, PubMed:22357926). Escaper adult flies display weak motor activity, lethargic behavior, and shortened life span (PubMed:1427077). RNAi-mediated knockdown of the protein in type II neuroblasts lineage results in an increase in the number of type II neuroblasts (PubMed:28899667). Simultaneous RNAi-mediated knockdown of the ETS protein pnt or the transcriptional repressor Erm restores normal neuroblast numbers (PubMed:28899667). {ECO:0000269|PubMed:1427077, ECO:0000269|PubMed:21262215, ECO:0000269|PubMed:22357926, ECO:0000269|PubMed:23056424, ECO:0000269|PubMed:28899667}. |