| 36089 | A1Z877 | NDG_DROME | Nidogen (Entactin) | DISRUPTION PHENOTYPE | Reduces fertility (PubMed:30260959, PubMed:30567930). In larvae results in impaired climbing abilities and in multiple holes in the basal membrane surrounding the fat body adipose, the somatic muscles and the longitudinal and circular visceral muscles, affecting permeability and mechanical stability of the basement membrane (PubMed:30260959, PubMed:30567930). Impairs larvae movement including reduced crawling speed, smaller stride frequency and exploration area together with sudden motion defects in their crawling pattern, such as head shaking, and spontaneous rolling and bending (PubMed:30567930). Increases neuromuscular junction (NMJ) size including abnormal branching numbers, overall branch length and enhanced bouton density suggesting defective NMJ maturation (PubMed:30567930). Reduces reaction to vibrational stimuli with partial loss of alignment of sensory cilia and morphological defects of the larval peripheral nervous system (PubMed:30567930). Results in smaller pupae presenting an orientation shift of the pupal cases towards the horizontal axis (PubMed:30567930). Results in incompletely inflated wing blades in a small group of adults (PubMed:30567930). {ECO:0000269|PubMed:30260959, ECO:0000269|PubMed:30567930}. |