| 36150 | A1Z8D0 | PWP1_DROME | Periodic tryptophan protein 1 homolog (PWP1) (Protein no child left behind) | DISRUPTION PHENOTYPE | Larval mutants exhibit altered cell transcription with reduced levels of Pol I-dependent rRNA biogenesis and, to a certain extent, of III-dependent transcription leading to reduced growth (PubMed:21752937, PubMed:29065309). Displays delayed pupation kinetics and reduced pupal volume (PubMed:29065309). Exhibits reduced number of germline cells leading to fertility defects; female flies have limited fertility, whereas male flies are sterile (PubMed:21752937). In male larvae, germ cells can enter differentiation but spermatogenic cysts cannot develop normally (PubMed:21752937). Adult testes shows fewer hub-proximal germ cells, lack of Stat92e activation and general failure of germline stem cells (GSC) maintenance (PubMed:21752937). RNAi-mediated knockdown in the posterior compartment of the developing wing leads to reduced compartment size (PubMed:29065309). RNAi-mediated knockdown in the fat body results in delayed larval development and reduced pupal volume (PubMed:29065309). {ECO:0000269|PubMed:21752937, ECO:0000269|PubMed:29065309}. |