| 36281 | A1Z8R8 | PARL_DROME | Presenilins-associated rhomboid-like protein, mitochondrial (EC 3.4.21.105) (Mitochondrial intramembrane-cleaving protease Parl) (Rhomboid-7) | DISRUPTION PHENOTYPE | Lethal with most dying before pupation (PubMed:16713954). Mitochondria in the testis and skeletal muscles display morphological defects indicative of defective mitochondrial fusion (PubMed:16713954). The few escapers that survive to adulthood, display neurological defects, male sterility, and do not survive for longer than three days (PubMed:16713954). Also displays photoreceptor degeneration after prolonged light stimulation and abnormal photoreceptor synaptic function which specifically affects both the generation of light responses and the signal transfer across the first visual synapse (PubMed:16713954). {ECO:0000269|PubMed:16713954}. |