Mine Disruption Phenotype

Gene Info

  • Species:Fly (Drosophila melanogaster)
  • GeneID:37272
  • Symbol:Toll-7
  • Description:Toll-7
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Gene ID Entry Entry Name Protein Name Type Information
37272 Q7KIN0 TOLL7_DROME Toll-like receptor 7 DISRUPTION PHENOTYPE Mistargeting of VA1d ORN axons to a medial position (PubMed:25741726). No effect on the immune response to septic injury using a mixture of Gram-positive and Gram-negative bacteria; adults are able induce expression of antibacterial peptide genes (Drs, AttA, DptA and Mtk) and mount a proper innate immune response (PubMed:21158756). RNAi-mediated knockdown results in adults that are acutely sensitive to the vesicular stomatitis virus (vsv) (PubMed:22464169). Following infection with vsv adult survival is decreased, and adults show a dramatic increase in viral RNA production 6 days post vsv infection and viral replication 9 days post infection (PubMed:22464169). Reduced autophagy in adult fat body cells following vsv infection (PubMed:22464169). Starvation-induced autophagy is not affected (PubMed:22464169). {ECO:0000269|PubMed:21158756, ECO:0000269|PubMed:22464169, ECO:0000269|PubMed:25741726}.