| 37636 | F3YDF1 | YMEL1_DROME | ATP-dependent zinc metalloprotease YME1L (EC 3.4.24.-) (YME1-like ATPase) | DISRUPTION PHENOTYPE | Viable but lifespan is reduced and males are sterile. Mitochondrial proteostasis is disrupted leading to crista disorganization, mitochondrial unfolded protein stress and impaired complex I activity which increases levels of reactive oxygen species (ROS). These defects all likely contribute to the increase in Dronc-mediated apoptosis in neuromuscular tissue. The severity of the mitochondrial abnormalities and their resulting phenotypes increase with age, resulting in the progressive degeneration of photoreceptor neurons and locomotor activity and increased sensitivity to genetic and environmental stresses. {ECO:0000269|PubMed:26160069}. |