| 37938 | Q9W133 | ADCK_DROME | AarF domain-containing kinase 1 (EC 2.7.-.-) | DISRUPTION PHENOTYPE | RNAi-mediated knockdown is larval lethal (PubMed:31175694, PubMed:31125351). RNAi-mediated knockdown in adults results in the thoracic muscles displaying abnormally orientated fibers as well as an abnormal increase in mitochondrial fusion resulting in mitochondrial dysfunction in ATP production, ROS generation and cell apoptosis (PubMed:31125351). Consequently, adults display a held-up wing phenotype, are unable to fly and also display defects in locomotion (PubMed:31125351). RNAi-mediated knockdown in salivary glands also results in an increase in mitochondrial fusion (PubMed:31125351). RNAi-mediated knockdown in the trachea results in arrested development at either the first or second instar larval stage (PubMed:31175694). In addition the larvae display tracheal defects, such as tracheal breaks and lumen separation, and prematurely wander away from food (PubMed:31175694). {ECO:0000269|PubMed:31125351, ECO:0000269|PubMed:31175694}. |