| 38099 | Q9W0M1 | CE290_DROME | Centrosomal protein cep290 | DISRUPTION PHENOTYPE | Adults are severely uncoordinated and exhibit disorganized spermatid cysts with dispersed nuclei, likely as a consequence of the severe defects in axonemal elongation (PubMed:31821146). RNAi-mediated knockdown in developing sensory neurons results in defective microtubule (MT)-microtubule (MT) and microtubule-membrane connections (Y linkers) ultimately affecting cilia formation leading to olfactory and gravitaxis behavioral defects (PubMed:30013109). RNAi-mediated knockdown in spermatocytes results in defective transition zone assembly including increased distance between microtubules (MT) and MT-membrane causing defective cilia (PubMed:30013109). {ECO:0000269|PubMed:30013109, ECO:0000269|PubMed:31821146}. |