| 38153 | Q23979 | MY61F_DROME | Unconventional myosin IC (MyoIC) (Brush border myosin IB) (BBMIB) (Myosin-IB) (MIB) (Unconventional myosin 1C) (Myo1C) | DISRUPTION PHENOTYPE | Viable and fertile, but adults have a shortened lifespan. Flies deficient in both Myo31DF and Myo61F are viable and fertile, but adults have a shorter lifespan than single mutants. Flies deficient in Myo61F show normal left-right asymmetry of the embryonic gut and normal, dextral rotation of male genitalia, and the same is observed in mutants deficient in both Myo61F and Myo95E. Mutants deficient in Myo31DF and Myo61F display stronger sinistral rotation of the male genitalia than mutants deficient for Myo31DF (PubMed:25659376). RNAi-mediated knockdown causes defects in embryonic midgut laterality, but only with low-frequency (PubMed:16598258). RNAi-mediated knockdown has no effect on normal, dextral rotation of male genitalia (PubMed:22491943). Combined RNAi-mediated knockdown of Myo31DF and Myo61F gives rise to the same phenotype as knockdown of Myo31DF alone, i.e sinistral rotation of the male genitalia (PubMed:22491943). {ECO:0000269|PubMed:16598258, ECO:0000269|PubMed:22491943, ECO:0000269|PubMed:25659376}. |