| 38218 | Q9W0A0 | DRPR_DROME | Protein draper | DISRUPTION PHENOTYPE | Embryos show no defects in early central nervous system (CNS) development but display defective CNS cell corpse engulfment (PubMed:12765609). Increased number and volume of apoptotic particles in the nerve cord (PubMed:18455990). Suppression of glial engulfment of larval axons which results in defective axon pruning with most larval axons remaining in the mushroom body dorsal lobe at 18 hours after puparium formation in contrast to the wild-type where most of the larval axons are pruned by this time (PubMed:16772168, PubMed:16772170). Failure of glia to respond to axon injury, resulting in severed axons not being cleared from the CNS (PubMed:16772169). Impaired clearance of degenerating dendrites (PubMed:24412417). Highly abnormal neuromuscular junctions characterized by reduced synaptic growth, the accumulation of presynaptic debris and pruned ghost boutons, and reduced larval mobility (PubMed:19707574). Significant defects in germ cell engulfment by follicle cells (PubMed:22992958). Defective larval salivary gland death with persistance of salivary gland material in 98% of mutants 24 hours after puparium formation (PubMed:20577216). Reduced hemocyte phagocytosis of S.aureus following infection with infected flies dying earlier than controls (PubMed:19890048). Following wounding, impaired migration of macrophages to wound sites (PubMed:26028435). Reduced lifespan (PubMed:25111228, Ref.27). Reduced climbing performance and impaired motor function with mutants displaying abnormal positioning of the legs and a rapid age-dependent decline in locomotor activity from 3 days to 7-10 days of adult life (PubMed:25111228). In 30-40 day old flies, pathological changes in thoracic skeletal muscle, such as loss of striation, variability in fiber size and vacuolization, that mainly affect the tergal depressor of the trochanter.(PubMed:25111228) Marked degeneration and vacuolization of the nervous system including brain and thoracic ventral ganglia, and degeneration of the retina and optic ganglia (PubMed:25111228). RNAi-mediated knockdown results in greatly reduced phagocytosis of apoptotic cells (PubMed:15342648). RNAi-mediated knockdown in neurons does not affect clearance of axon fragments resulting from developmental axon pruning but RNAi-mediated knockdown in glial cells results in defective clearance of axon fragments (PubMed:16772170). RNAi-mediated knockdown in the mesoderm or in adult precursor muscle cells results in impaired locomotor activity which is not seen following RNAi-mediated knockdown in neurons or glia (PubMed:25111228). {ECO:0000269|PubMed:12765609, ECO:0000269|PubMed:15342648, ECO:0000269|PubMed:16772168, ECO:0000269|PubMed:16772169, ECO:0000269|PubMed:16772170, ECO:0000269|PubMed:18455990, ECO:0000269|PubMed:19707574, ECO:0000269|PubMed:19890048, ECO:0000269|PubMed:20577216, ECO:0000269|PubMed:22992958, ECO:0000269|PubMed:24412417, ECO:0000269|PubMed:25111228, ECO:0000269|PubMed:26028435}. |