Mine Disruption Phenotype

Gene Info

  • Species:Fly (Drosophila melanogaster)
  • GeneID:38516
  • Symbol:ago
  • Description:archipelago
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Gene ID Entry Entry Name Protein Name Type Information
38516 Q9VZF4 FBXW7_DROME F-box/WD repeat-containing protein 7 (F-box and WD-40 domain-containing protein 7) (Protein archipelago) DISRUPTION PHENOTYPE RNAi-mediated knockdown in the posterior compartment of the larval wing disk increases cell size in the posterior compartment of the adult wing, resulting in an increase in the size of the posterior compartment as well as an increase in the ratio between the posterior and anterior areas. Knockdown of the gene is embryonic lethal. Neuronal-specific knockdown results in deficits in habituation learning, as demonstrated by the light-off reflex habituation assay. {ECO:0000269|PubMed:24173801, ECO:0000269|PubMed:35395208}.