| 38648 | Q9VRP5 | UBP36_DROME | Ubiquitin carboxyl-terminal hydrolase 36 (EC 3.4.19.12) (Deubiquitinating enzyme 36) (Protein scrawny) (Ubiquitin thioesterase 36) (Ubiquitin-specific-processing protease 36) | DISRUPTION PHENOTYPE | Mutants are lethal at larval stages (PubMed:19837371, PubMed:22622177). They are significantly smaller without gross morphological defects and die 5 days after egg laying (PubMed:22622177). Cells show accumulation of ubiquitinated proteins in both the nucleus and the cytoplasm, forming dense dots (PubMed:22622177). Double mutants for ref(2)P and scny die 96 hours after egg laying (PubMed:22622177). RNAi-mediated knockdown is also larval lethal (PubMed:19837371). RNAi-mediated knockdown in the fat body or gut of uninfected adults, results in a significant increase in the expression of the antimicrobial peptide genes Dpt, AttA and puc (PubMed:19837371). Adults raised under axenic conditions do not display any increase in Dpt, AttA and puc expression (PubMed:19837371). No significant increase in the expression of the antifungal peptide gene Drs (PubMed:19837371). Double knockdown with imd in the adult fat body, prevents the enhanced expression of Dpt in uninfected flies (PubMed:19837371). {ECO:0000269|PubMed:19837371, ECO:0000269|PubMed:22622177}. |