| 39018 | Q9VSR3 | ORB2_DROME | Translational regulator orb2 | DISRUPTION PHENOTYPE | Substantially reduced viability with surviving males being completely sterile due to a failure of spermatocytes to complete meiosis with arrest happening at the G2-M transition (PubMed:23209437). Defective spermatid cyst polarization (PubMed:24830287). RNAi-mediated knockdown in motor neurons decreases number of synapses and accumulation of the tumor suppressor brat at neuromuscular junctions (NMJ) (PubMed:29105522). Simultaneous knockdown of the tumor suppressor brat restablishes the number of synapses at NMJ (PubMed:29105522). {ECO:0000269|PubMed:23209437, ECO:0000269|PubMed:24830287, ECO:0000269|PubMed:29105522}.; DISRUPTION PHENOTYPE: [Isoform A]: Fails to form stable long-term memory during male courtship suppression, in which a male fly, upon repeated exposure to an unreceptive female, suppresses its courting behavior for days (PubMed:28525754). In neurons, increases levels of the tumor suppressor brat (PubMed:29105522). {ECO:0000269|PubMed:28525754, ECO:0000269|PubMed:29105522}. |