| 40754 | Q9VNM1 | NPFR_DROME | Neuropeptide F receptor (DmNPFR1) | DISRUPTION PHENOTYPE | Increased NPF or NPFR activity dominantly suppresses PAIN-mediated food aversion in postfeeding larvae. Deficiency in NPF/NPFR signaling causes decreased alcohol sensitivity and overexpression causes a hypersensitive response to alcohol sedation. Controlled functional disruption of NPF or NPFR neurons rapidly triggers acute resistance to ethanol sedation. {ECO:0000269|PubMed:11897397, ECO:0000269|PubMed:15677721, ECO:0000269|PubMed:20164335, ECO:0000269|PubMed:22422983}. |