| 42591 | P91929 | NDUAA_DROME | NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 10, mitochondrial (Complex I-42kD) (CI-42kD) (NADH-ubiquinone oxidoreductase 42 kDa subunit) | DISRUPTION PHENOTYPE | RNAi-mediated knockdown leads to loss of ND-30 and reduced mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I) activity (PubMed:23509070). Larvae exhibit elevated reactive oxygen species (ROS) and an up-regulation of Hsp60 (PubMed:23509070). RNAi-mediated knockdown in the eye results in retinal degeneration exacerbated with aging and accompanied by high levels of ROS and accumulation of lipid droplets in the glia (PubMed:23509070, PubMed:25594180). RNAi-mediated knockdown in neurons results in lipid droplet accumulation and increased levels of peroxidated lipids (PubMed:25594180). {ECO:0000269|PubMed:23509070, ECO:0000269|PubMed:25594180}. |