Mine Disruption Phenotype

Gene Info

  • Species:Fly (Drosophila melanogaster)
  • GeneID:42665
  • Symbol:Efa6
  • Description:Exchange factor for Arf 6
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Gene ID Entry Entry Name Protein Name Type Information
42665 E1JIT7 PSD_DROME PH and SEC7 domain-containing protein (Exchange factor for ADP-ribosylation factor guanine nucleotide factor 6) (Exchange factor for Arf 6) DISRUPTION PHENOTYPE Viable but male sterile (PubMed:28607459). Results in enhances preference and sensitivity to ethanol (PubMed:28607459). Fails to develop tolerance to repeated ethanol exposures (PubMed:28607459). Increases axon length and axon branching (PubMed:31718774). RNAi-mediated knockdown increases axon length and axon branching (PubMed:31718774). RNAi-mediated knockdown in a subset of lamina neurons results in axonal swellings and disorganized axonal microtubules (PubMed:31718774). {ECO:0000269|PubMed:28607459, ECO:0000269|PubMed:31718774}.