| 42896 | P10040 | CRB_DROME | Protein crumbs (95F) | DISRUPTION PHENOTYPE | Flies show severe disruptions in the organization of ectodermally derived epithelia and leading in some cases to cell death in these tissues (PubMed:2344615). RNAi-mediated knockdown in the whole body or tracheae results in depletion of its binding partner sdt, twisted tracheal tubes, lack of gas filling and reduced apical surfaces of tracheal tube cells with death occurring at larval stage 2 or 3 (PubMed:30645584). RNAi-mediated knockdown in germline cells results in severe chromosomal and spindle microtubule defects such as chromosome bridges, bent chromosomes, monopolar spindles and fusion with one or more neighboring spindles (PubMed:25065591). {ECO:0000269|PubMed:2344615, ECO:0000269|PubMed:25065591, ECO:0000269|PubMed:30645584}. |