| 43999 | Q9V3Z1 | TRIB_DROME | Tribbles | DISRUPTION PHENOTYPE | Low viability with only 14% of mutants survive to adulthood (PubMed:10850493). The egg chambers of surviving females often have only eight germline cysts half of which have an oocyte and the other half do not (PubMed:10850493). Early stage 9 to stage 10 embryos, display increased levels of slbo (PubMed:10949024). RNAi-mediated knockdown in embryos produces premature mitosis in part or all of the ventral region, resulting in many mutants displaying defects in gastrulation including partial invagination of the mesoderm (PubMed:10837248). RNAi-mediated knockdown results in an increase in phosphorylated Akt1 but has no effect on total Akt1 levels (PubMed:25329475, PubMed:29025897). RNAi-mediated knockdown in the fat body increases lipid accumulation, larval weight, fat body cell size and the size of fat body nuclei (PubMed:25329475). The increase in larval weight results in delayed pupariation (PubMed:25329475). Flies also display an increase in triglyceride levels which is consistent with the increase in the number and size of lipid bodies (PubMed:25329475). RNAi-mediated knockdown in the fat body does not result in a significant change in triglyceride levels but flies display an increase in glycogen levels and an increase in lipid droplet size (PubMed:29025897). No effect on glucose or trehalose levels in the hemolymph (PubMed:25329475, PubMed:29025897). RNAi-mediated knockdown in late stage border cells, partially reduced border cell migration (PubMed:23305818). {ECO:0000269|PubMed:10837248, ECO:0000269|PubMed:10850493, ECO:0000269|PubMed:10949024, ECO:0000269|PubMed:23305818, ECO:0000269|PubMed:25329475, ECO:0000269|PubMed:29025897}. |