Mine Disruption Phenotype

Gene Info

  • Species:Fly (Drosophila melanogaster)
  • GeneID:44039
  • Symbol:Pak
  • Description:p21-activated kinase
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Gene ID Entry Entry Name Protein Name Type Information
44039 Q9VI13 PAK_DROME Serine/threonine-protein kinase Pak (EC 2.7.11.1) DISRUPTION PHENOTYPE Homozygous knockout flies show defective wing morphology. Mutant embryos show guidance phenotypes in ventral oblique muscle 5 (VO5), ventral oblique muscle 6 (VO6) and ventral acute muscle 3 (VA3). The affected muscles bypass their normal ventral attachment sites and mistarget toward or crossing the ventral midline. Mutant embryos exhibit additional muscle phenotypes, such as increase in lateral transverse (LT) muscles and VA3 numbers and defective lateral oblique muscle 1 (LO1) and ventral oblique muscle 1 (VO1) shape. {ECO:0000269|PubMed:18996366}.