Mine Disruption Phenotype

Gene Info

  • Species:Fly (Drosophila melanogaster)
  • GeneID:44353
  • Symbol:Shark
  • Description:SH2 ankyrin repeat kinase
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Gene ID Entry Entry Name Protein Name Type Information
44353 Q24145 SHARK_DROME Tyrosine-protein kinase Shark (EC 2.7.10.2) DISRUPTION PHENOTYPE Strong reduction in the number of macrophages recruited to wound sites (PubMed:26028435). RNAi-mediated knockdown in glial cells abolishes a number of events which normally occur following axon injury including drpr localization at severed axons, glial recruitment to severed axons, up-regulation of drpr in glial cells and clearance of axonal debris from the central nervous system (PubMed:18432193). {ECO:0000269|PubMed:18432193, ECO:0000269|PubMed:26028435}.