| 44497 | Q9V477 | TOLL8_DROME | Toll-like receptor Tollo (Toll-like receptor 8) | DISRUPTION PHENOTYPE | Viable (PubMed:18000549, PubMed:22022271). The legs of some adults have the correct number of segments but are bent between the tibia and tarsus, causing the leg to twist in the wrong direction (PubMed:21158756). Formation of ectopic bristles on the heminota (PubMed:18000549). Slight decrease in the branch length of NMJ3 and a reduced number of boutons at NMJ3 and NMJ4 (PubMed:24662564). In larvae, tracheal cell morphology is normal and basal expression levels of the AMP gene Drs are unaffected (PubMed:22022271). However after infection with Gram-negative bacteria, the respiratory epithelium displays an over-active immune response with a greater increase in expression of AMPs (Drs, Dro and AttC) compared to wild-type larvae (PubMed:22022271). In adults, no effect on the immune response to septic injury using a mixture of Gram-positive and Gram-negative bacteria; adults are able induce expression of antibacterial peptide genes (Drs, AttA, DptA and Mtk) and mount a proper innate immune response (PubMed:21158756). No visible effect on the development of the embryo central nervous system (PubMed:21158756). {ECO:0000269|PubMed:18000549, ECO:0000269|PubMed:21158756, ECO:0000269|PubMed:22022271, ECO:0000269|PubMed:24662564}. |