| 44669 | Q9VGZ5 | CWO_DROME | Transcription factor cwo (Protein clockwork orange) | DISRUPTION PHENOTYPE | Strong circadian locomotor phenotype with most mutants being arrhythmic after 4 days in constant darkness and displaying a long period in both light/dark and constant dark conditions (PubMed:17578907). Delayed evening activity peak in light/dark conditions and robust 26.5 hour rhythms for at least 10 days in constant darkness (PubMed:18375860). Reduced circadian oscillation of Clk target genes per, tim, vri and Pdp1 (PubMed:17578907, PubMed:18375860). RNAi-mediated knockdown results in a lengthened circadian period (PubMed:17555964, PubMed:17578908). {ECO:0000269|PubMed:17555964, ECO:0000269|PubMed:17578907, ECO:0000269|PubMed:17578908, ECO:0000269|PubMed:18375860}. |