Mine Disruption Phenotype

Gene Info

  • Species:Fly (Drosophila melanogaster)
  • GeneID:45821
  • Symbol:Abl
  • Description:Abl tyrosine kinase
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Gene ID Entry Entry Name Protein Name Type Information
45821 P00522 ABL_DROME Tyrosine-protein kinase Abl (EC 2.7.10.2) (D-ash) (Protein abelson) DISRUPTION PHENOTYPE Both loss- and gain-of-function mutants exhibit neurons within the pCC/MP2 pathway that incorrectly project across the midline. Loss of Abl disrupts cell migration and cell shape changes during dorsal closure. {ECO:0000269|PubMed:11756472, ECO:0000269|PubMed:9635189}.