| 47594 | A1Z9X0 | APKC_DROME | Atypical protein kinase C (EC 2.7.11.13) | DISRUPTION PHENOTYPE | Zygotes survive to mid-larval stages where they exhibit defects in neuroblast and epithelial cell polarity. Mutant neuroblasts lack apical localization of l(2)gl and par-6, and fail to exclude mira from the apical cortex. Oocytes do not differentiate and display failure of BicD and ORB to translocate from the anterior to the posterior crescent, accumulation of Dhc64C in the two posterior-most presumptive pre-oocytes instead of in a single cell as normal, and defective posterior assembly of the microtubule organizing center. Adherens junctions form atypical planar-polarized puncta at gastrulation. Reduced yrt phosphorylation. {ECO:0000269|PubMed:11734648, ECO:0000269|PubMed:14657233, ECO:0000269|PubMed:17488624, ECO:0000269|PubMed:24515345}. |