| 50070 | Q9VCA8 | ANKHM_DROME | Ankyrin repeat and KH domain-containing protein mask (Multiple ankyrin repeat single KH domain-containing protein) | DISRUPTION PHENOTYPE | Flies exhibit compromised photoreceptor differentiation, cell survival and proliferation (PubMed:11782402). RNAi-mediated knockdown in muscles causes severe lethality at the early pupal stage and the few surviving animals cannot fly (PubMed:26251439). Severe defects in the indirect flight muscle structure characterized by narrower myofibrils and abnormal positioning of sarcomere Z line, M line and H line (PubMed:26251439). Although the spacing between Z line and M lines stays regular, M lines are not straight and sarcomere length is shorter. In the more affected myofibrils, the sarcomere structure is lost (PubMed:26251439). Localization of unc-89/obscurin to M lines and localization of kettin (sls isoform A) to Z line is not affected (PubMed:26251439). {ECO:0000269|PubMed:11782402, ECO:0000269|PubMed:26251439}. |