Mine Disruption Phenotype

Gene Info

  • Species:Zebrafish (Danio rerio)
  • GeneID:393286
  • Symbol:odad4
  • Description:outer dynein arm docking complex subunit 4
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Gene ID Entry Entry Name Protein Name Type Information
393286 Q7ZU45 ODAD4_DANRE Outer dynein arm-docking complex subunit 4 (Tetratricopeptide repeat protein 25) (TPR repeat protein 25) DISRUPTION PHENOTYPE Morpholino knockdown of the protein causes severe curvature of the body at 72 hpf. Morphants also exhibit hydrocephalus, abnormal otoliths and disturbed left-right asymmetry patterning. Some animals (17%) tend to develop pronephric cysts. At the 7-somite stage, cilia number and length are reduced in the Kupffer's vesicle. At 60 hpf, cilia motility is markedly impaired in the pronephric duct. {ECO:0000269|PubMed:25860617}.