Mine Disruption Phenotype

Gene Info

  • Species:Zebrafish (Danio rerio)
  • GeneID:404627
  • Symbol:six1b
  • Description:SIX homeobox 1b
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Gene ID Entry Entry Name Protein Name Type Information
404627 Q6NZ04 SIX1B_DANRE Homeobox protein six1b (Homeobox protein six1a) (Sine oculis homeobox homolog 1a) (Sine oculis homeobox homolog 1b) DISRUPTION PHENOTYPE Morpholino knockdown of the protein increases both cell proliferation and apoptosis in the otocyst. Increases proliferation of neuronal cells and decreases the number of cells destined to form hair cells. Disrupts myogenesis by interfering with the proliferation of dermomyotomal cells expressing pax7 and loss of myog expression. {ECO:0000269|PubMed:17035528, ECO:0000269|PubMed:18789916, ECO:0000269|PubMed:19409884, ECO:0000269|PubMed:23444384}.