| 405851 | Q6NW58 | SPAST_DANRE | Spastin (EC 5.6.1.1) | DISRUPTION PHENOTYPE | Branchiomotor neurons exhibit reduced axonal outgrowth and aberrant positioning of neuronal cell bodies. Outgrowth of motor axons from the spinal cord is impaired, the number and length of spinal motor neurons is reduced, and elevated levels of apoptosis are observed in the CNS. Thickened bundles of axonal microtubules are observed in the spinal cord. Longitudinal fascicles in the hindbrain are disordered. Most embryos are immotile and fail to hatch, while those that do exhibit reduced motility and swimming defects. Morpholino knockdown results in abnormal morphological features, including hydrocephalia, perturbed yolk sac extension and an arched-back phenotype, disorganized microtubule networks in the spinal cord and thinner microtubules in the spinal motor neuron axons, and in increased oxidative stress (PubMed:26744324). These phenotypes are rescued following exposure to the drugs methylene blue, guanabenz, salubrinal or phenazine (PubMed:26744324). {ECO:0000269|PubMed:16893913, ECO:0000269|PubMed:26744324}. |