| 432387 | Q6IVV8 | PKD2_DANRE | Polycystin-2 (Curly up) (Cup) (Polycystic kidney disease 2 protein homolog) (Transient receptor potential cation channel subfamily P member 2) | DISRUPTION PHENOTYPE | Morpholino knockdown of the protein impairs specification of the left-right axis during embryonic development and randomization of heart and gut looping, plus misexpression of left-side specific genes (PubMed:16216239, PubMed:16943304, PubMed:17360770, PubMed:26432887, PubMed:25660539). Morpholino knockdown of the protein causes body curvature, tail curling, hydrocephalus and kidney cysts (PubMed:15269167, PubMed:16216239, PubMed:16943304, PubMed:16551655, PubMed:17360770, PubMed:23376035, PubMed:26432887). Morpholino knockdown has no effect on number, length or motility of pronephric cilia, but the fluid flow through the pronephric ducts seems to be impaired due to physical obstruction of the ducts (PubMed:16943304). Likewise, morpholino knockdown of the protein has no effect on the motility of cilia in Kupffer's vesicle (PubMed:25660539). Morpholino knockdown of the protein leads to an increase of the volume of Kupffer's vesicle, without any change in the proliferation of the cells that line the vesicle (PubMed:26432887). Morpholino knockdown of the protein leads to impaired heart function, characterized by arrhytmia and frequently associated with pericardial and abdominal edema and atrioventricular block (PubMed:23376035). {ECO:0000269|PubMed:15269167, ECO:0000269|PubMed:16216239, ECO:0000269|PubMed:16551655, ECO:0000269|PubMed:16943304, ECO:0000269|PubMed:17360770, ECO:0000269|PubMed:23376035, ECO:0000269|PubMed:26432887}. |