| 557044 | B8JI71 | EYS_DANRE | Protein eyes shut homolog | DISRUPTION PHENOTYPE | Progressive loss of cone photoreceptors in the retina from two months post-fertilization (mpf) onwards, with almost complete loss by 9 mpf. Rod photoreceptors also show signs of degeneration in older animals of 14 mpf. Photoreceptor degeneration is accompanied by increased apoptosis and mislocalization of outer segment proteins. At the ultrastructural level, morphology of the photoreceptor ciliary pocket is frequently abnormal with either complete collapse of the pocket, or presence of multiple membranous vesicles. {ECO:0000269|PubMed:27737822}. |