| 559562 | E7F9L8 | MYO1D_DANRE | Unconventional myosin-Id (Myosin 1d) (Myosin1D) | DISRUPTION PHENOTYPE | Morpholino knockdown of the protein causes situs inversus, a left-right asymmetry defect where organs are placed at a position corresponding to the mirror image of the normal body plan. Causes laterality defects at the level of the heart, viscera and brain (PubMed:29769531). Morpholino knockdown of the protein leads to the formation of a Kupffer's vesicle with reduced volume and dismorphic shape. Morpholino knockdown of the protein interferes with the normal cellular remodeling that gives rise to anterior-posterior asymmetry of Kupffer's vesicle. Cells with a columnar shape persist at the posterior end of the vesicle, contrary to wild-type, where cells display columnar shape at the anterior part of the vesicle, and squamous or cuboidal shape at the posterior end of Kupffer's vesicle. Epithelial cells lining Kupffer's vesicle display an increased number of vacuoles, and disruption of the normal, directed vacuolar trafficking toward the apical cell membrane (PubMed:30139971). {ECO:0000269|PubMed:29769531, ECO:0000269|PubMed:30139971}. |