Mine Disruption Phenotype

Gene Info

  • Species:Zebrafish (Danio rerio)
  • GeneID:561935
  • Symbol:aplnra
  • Description:apelin receptor a
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Gene ID Entry Entry Name Protein Name Type Information
561935 Q7SZP9 APJA_DANRE Apelin receptor A (Angiotensin II receptor-like 1a) (Angiotensin receptor-like 1a) (G-protein coupled receptor APJ A) DISRUPTION PHENOTYPE Morpholino knockdown of the protein induces embryonic lethality due to cardiac dysplasia with little to no blood circulation around 6 days post-fertilization (dpf) (PubMed:24316148). Mutant embryos show pericardial edema and accumulation of erythrocytes in the intermediate cell mass (ICM) at 30 hours post-fertilization (hpf) (PubMed:24316148). Display decreased angioblast migration to the embryonic midline during late gastrulation (PubMed:24316148, PubMed:24407481, PubMed:26017639). {ECO:0000269|PubMed:24316148, ECO:0000269|PubMed:24407481, ECO:0000269|PubMed:26017639}.